During the Revolution, fighting in what is now West Virginia continued earlier frontier wars, like the French and Indian War, involving Indian raids on settlers with British support. The Shawnee were particularly active, attacking settlements and forts, sometimes with loyalist aid.

The year 1777 was especially brutal, marked by the siege of Fort Henry and the Foreman Massacre, along with numerous smaller raids, earning it the nickname "year of the bloody sevens."

The fighting persisted until the war's end, with attacks on Fort Randolph in 1778, Fort Donnally in 1779, and another assault on Fort Henry in 1782, nearly a year after the British surrender at Yorktown.

Sporadic Indian attacks continued until the Battle of Fallen Timbers.