This Pocahontas County native studied sculpture in Washington and Philadelphia, where she learned from Albert Laessle, a sculptor who focused on animals. Since Tuke loved horseback riding, she often sculpted horses.

In the 1930s, Tuke started working with pottery while teaching at the Greenbrier art colony. During World War II, she taught pottery and sculpture at the Greenbrier's U.S. Army hospital. After the war, she opened her own pottery and sculpture studio in White Sulphur Springs. She used clay from her own land to make her pottery.

Tuke showed her work in places like the Pennsylvania Academy of the Fine Arts and the Corcoran Gallery. She also taught pottery and gave demonstrations to Greenbrier guests and local groups.